Other Drugs Affect the Way Indomethacin Works? Indomethacin does not lower uric acid levels in the body. If they fail, then an additional medication may need to be added.What other drugs will affect? Ask your doctor before using if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.(naproxen) is an anti-inflammatory drug used to treat pain and inflammation in arthritis, Drugs; OTC Drugs; International Drugs; Natural Products; Veterinary Products; Info en Espa?ol; Drug Side Effects; Dosage Guides; Pregnancy Warnings;